Pyridoxylamine

SKU: orb1309202

Description

Pyridoxamine is a small molecule inhibitor of advanced glycation end products (AGEs) and advanced lipoxidation end products (ALEs). It is widely used in research to study diabetic complications, aging, and neurodegenerative diseases in both in vitro and in vivo experimental models.

Research Area

Metabolism Research

Key Properties

• CAS Number: 85-87-0
• MW: 168.19
• Purity: 99.66% (May vary between batches)
• Formula: C₈H₁₂N₂O₂
• SMILES: C(N)C=1C(CO)=CN=C(C)C1O
• Target: Endogenous Metabolite
• Solubility: DMSO:65 mg/mL (386.47 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (11.89 mM);H2O:6.25 mg/mL (37.16 mM)

Bioactivity

• In Vivo:
  In STZ diabetic rats, Pyridoxylamine inhibited the formation of CML and CEL and the cross-linking of skin collagen, ultimately inhibiting the development of nephropathy. Pyridoxamine does not appear to act as an antioxidant because it does not inhibit lipid peroxidation. However, it prevents modification of proteins by lipid peroxidation products, including inhibition of the formation of adducts of malondialdehyde and 4-hydroxynonenal on proteins in Zucker rats .
• In Vitro:
  Pyridoxylamine (PM) is a member of the B6 vitamer family,and is a potent scavenger of reactive carbonyls, inhibiting the late stages of glycation reactions that lead to AGE formation.

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Endogenous Metabolite, Human Endogenous Metabolite, EndogenousMetabolite, Inhibitor, inhibit, pyridoxamine, Pyridoxylamine

Compound Identifiers

PubChem CID

1052