Pyridostatin

SKU: orb1706365

Description

Pyridostatin (RR82) is a synthetic G-quadruplex DNA stabilizer, targeting structures prevalent in telomeres and oncogene promoters. It is widely used in vitro to study telomere biology and in cancer research, where it has shown potential to inhibit tumor cell proliferation in vivo models.

Research Area

Cell Biology, Molecular Biology

Key Properties

• CAS Number: 1085412-37-8
• MW: 596.64
• Formula: C₃₁H₃₂N₈O₅
• SMILES: NCCOc1cc(nc(c1)C(=O)Nc1cc(OCCN)c2ccccc2n1)C(=O)Nc1cc(OCCN)c2ccccc2n1
• Target: DNA/RNA Synthesis
• Solubility: DMSO:20.85 mg/mL (34.95 mM);Ethanol:30.87 mg/mL (51.74 mM);H2O:9.66 mg/mL (16.19 mM)

Bioactivity

• Target IC50:
  G-quadruplexe:490 nM(Kd)
• In Vitro:
  Pyridostatin decreases the proliferation of MRC-5–SV40 cells and various cancer cell lines, and induces cell-cycle arrest by DNA-damage checkpoint activation. Pyridostatin also reduces SRC-dependent cell motility in MDA-MB-231 cells by interacting with G-quadruplex motifs in SRC. Pyridostatin decreases EBNA1 synthesis via inhibition of G-quadruplexes.
  Read more...
• Cell Research:
  Cells are plated at equal confluence and are left either untreated or were treated with 2 μM pyridostatin continually during the indicated time before harvesting the cells. Cells from individual plates are trypsinized and counted in a Coulter counter. Graphs represent the total cell numbers at each time interval, and the error bars represent the s.e.m. Data represent three independent experiments.(Only for Reference)
  Read more...

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

DNA Synthesis, DSB, DNASynthesis, G-quadruplex, neurodegeneration, RR 82, RR82, RR-82, RNASynthesis, RNA Synthesis, structure, Pyridostatin, Pyridostatin Trifluoroacetate Salt

Compound Identifiers

PubChem CID

25227847