Pyridostatin

SKU: orb1227014

Description

Pyridostatin Trifluoroacetate Salt is a G-quadruplexe stabilizer with Kd of 490 nM in a cell-free assay, which targets a series of proto-oncogenes including c-kit, K-ras and Bcl-2.

Key Properties

• CAS Number: 1085412-37-8
• MW: 596.64
• Purity: >98% (HPLC)
• Formula: C₃₁H₃₂N₈O₅
• SMILES: NCCOC1=CC(=NC(=C1)C(=O)NC1=NC2=CC=CC=C2C(OCCN)=C1)C(=O)NC1=NC2=CC=CC=C2C(OCCN)=C1
• Target: DNA/RNA Synthesis
• Solubility: Ethanol: 30 mg/mL 30; Water: 100 mg/mL 100; DMSO: 100 mg/mL 100

Bioactivity

• In Vitro:
  Pyridostatin (RR82) (10 μM; 48 hours) induces cell cycle arrest. Pyridostatin is a very selective G-quadruplex DNA-binding small molecule designed to form a complex with and stabilize G-quadruplex structure. Pyridostatin causes neurite retraction, synaptic loss, and dose-dependent neuronal death. In cultured primary neurons, Pyridostatin induces the formation of DNA DSBs. Remarkably, Pyridostatin (1-5 μM, overnight) down regulates the BRCA1 protein, a protein that guards and repairs the neuronal genome, at the transcriptional level. They are for reference only. Pyridostatin: Cell Viability Assay Cell line: Over 60 different cancer cell lines. Concentration: 10 μM. Incubation time: 48 hours. Result: Predominantly accumulated in the G2 phase of the cell cycle over 60 different cancer cell lines.

Storage & Handling

• Storage: Storage temperature: -20°C. Stability: ≥ 2 years
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Quick Database Links

Gene Symbol

DNA/RNA Synthesis