Pyrantel pamoate

SKU: orb1225628

Description

Pyrantel pamoate is a deworming agent in the treatment of hookworms (all species) and roundworms in domesticated animal; acts as a depolarizing neuromuscular blocking agent.(In Vitro):Pyrantel pamoate (10 nM-10 μM; 72 h) shows good anti-A. suum and (0-168.2 M; 72 h) anti-N. americanus activity.(In Vivo):Pyrantel pamoate (10 mg/kg; p.o.; single) reduces the worms in A. ceylanicum-infected hamsters, with the worm burden reduction of 87.2% and worm expulsion rate of 63.4%.

Key Properties

• CAS Number: 22204-24-6
• MW: 594.69
• Purity: >98% (HPLC)
• Formula: C₃₄H₃₀N₂O₆S
• SMILES: CN1CCCN=C1/C=C/c2cccs2.c1ccc2c(c1)cc(c(c2Cc3c4ccccc4cc(c3O)C(=O)O)O)C(=O)O
• Target: Antiparasitic
• Solubility: DMSO: 10 mM

Bioactivity

• In Vivo:
  Pyrantel pamoate (10 mg/kg; p.o. ; single) reduces the worms in A. ceylanicum-infected hamsters, with the worm burden reduction of 87.2% and worm expulsion rate of 63.4%. Animal model: Male Syrian Golden hamsters (3-week-old; A. ceylanicum-infected). Dosage: 10 mg/kg. Administration: Oral administration; single. Result: Exhibited worm burden reduction and worm expulsion rates of 87.2% and 63.4%, respectively.
• In Vitro:
  Pyrantel pamoate (10 nM-10 μM; 72 h) shows good anti-A. suum and (0-168.2 M; 72 h) anti-N. americanus activity. Cell Viability Assay Cell line: A. suum Concentration: 10 nM-10 μM. Incubation time: 72 h. Result: Inhibited A. suum with a pEC50 value of 7.24.Cell Viability Assay Cell line: N. americanus Concentration: 0-168.2 M (0-100 μg/mL) Incubation time: 72 h. Result: Inhibited third-stage larvae and adult of N. americanus with IC50 values of 2.0 and 7.6 mg/mL, respectively.

Storage & Handling

• Storage: Storage temperature: -20°C. Stability: ≥ 2 years
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Pyrantel pamoate

Quick Database Links

Gene Symbol

Antiparasitic