Pyr3

SKU: orb1307829

Description

Pyr3 is a potent and selective inhibitor of the TRPC3 ion channel, demonstrating dose-dependent inhibition of TRPC3-mediated calcium entry with an IC50 of 700 nM. This tool compound is widely used in cardiovascular and neurological research to investigate TRPC3 function in cellular signaling pathways, both in vitro and in vivo.

Research Area

Pharmacology & Drug Discovery

Key Properties

• CAS Number: 1160514-60-2
• MW: 456.63
• Purity: 99.47% (May vary between batches)
• Formula: C₁₆H₁₁Cl₃F₃N₃O₃
• SMILES: CCOC(=O)c1cnn(c1C(F)(F)F)-c1ccc(NC(=O)C(Cl)=C(Cl)Cl)cc1
• Target: TRP/TRPV Channel
• Solubility: 10% DMSO+40% PEG300+5% Tween 80+45% Saline:4 mg/mL (8.76 mM);DMSO:100 mg/mL (219 mM)

Bioactivity

• Target IC50:
  TRPC3:700 nM
• In Vitro:
  Pyr3 becomes apparent at 0.3 μM and is almost complete at 3 μM. Ca2+ influx is inhibited by Pyr3 in cells co-expressing TRPC3 plus TRPC6 but not in cells co-expressing TRPC1 plus TRPC5. The Ang II-induced NFAT translocation is suppressed by Pyr3 (IC50 = 0.05 μM), but weakly by Pyr2 (IC50 = 2 μM) in a concentration-dependent manner.

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Pyr3, Pyr-3, TRPV Channel, TRP Channel, TRPChannel, TRPC3, TRPVChannel

Compound Identifiers

PubChem CID

56964346