Punicalin

SKU: orb1302306

Description

Punicalin is a bioactive small molecule exhibiting anti-inflammatory, antioxidative, and hepatoprotective properties. It also acts as a dose-dependent inhibitor of HIV-1 reverse transcriptase with an IC50 of 0.14 µM, making it relevant for research in virology, hepatology, and oxidative stress models.

Research Area

Cell Biology, Immunology & Inflammation, Infectious Disease & Virology, Metabolism Research, Protein Biochemistry

Key Properties

• CAS Number: 65995-64-4
• MW: 782.53
• Purity: 99.95%
• Formula: C₃₄H₂₂O₂₂
• SMILES: OC1OC2COC(=O)c3cc(O)c(O)c(O)c3-c3c(O)c(O)c4oc(=O)c5c(c(O)c(O)c6oc(=O)c3c4c56)-c3c(O)c(O)c(O)cc3C(=O)OC2C(O)C1O
• Target: HBV,Pyroptosis,HIV Protease,Carbonic Anhydrase
• Solubility: DMSO:63.125 mg/mL (80.67 mM);H2O:100 mg/mL (127.79 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (2.56 mM)

Bioactivity

• Target IC50:
  HIV-1:0.11 microg/ml
• In Vivo:
  Punicalagin and punicalin were the active components of T. catappa L., a hepatoprotective crude drug used in Southern Asia, and both found to exhibit great antioxidant activity and hepatoprotective effect on CC14- or acetaminophen-induced liver damages. Even if they had great antioxidant effects in smaller concentration in vitro, treatment with larger doses of punicalagin and punicalin yield liver cell damage in rats. In studying their anti-inflammatory effects, similar results were also observed.
• In Vitro:
  The edema after carrageenan injection is believed to be biphasic in nature. The initial phase, beginning 1 hr after carrageenan administration, is due to the release of histamine and serotonin. The second phase occurs 2 to 5 hr after carrageenan administration. is induced by the release of bradykinin, protease, prostaglandin and lysosome . It has been reported that the second phase of edema is sensitive to most clinically effective anti-inflammatory agents, such as indomethacin. However, that treatment with punicalagin and punicalin is effective against both phases of inflammation induced by carrageenan.
• Animal Research:
  Edema in the left hind paw of rats was induced by injecting 0.05 ml of 1% (w/v) carrageenan into the limb. Animals were divided into six groups with eight animals in each group. The drug test groups were treated with 5 or 10 mg/kg body weight of each component 1 hr before carrageenan injection. The animals in the control group received saline. Another group of rats was administered 5 mg/kg indomethacin as a standard anti-inflammatory drug.

Storage & Handling

• Storage: keep away from direct sunlight | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

anti-inflammatory, inhibit, Inhibitor, HIV-1, HIV Protease, HIVProtease, HBV, hepatitis, Hepatitis B virus, Punicalin, Tannin, virus

Compound Identifiers

PubChem CID

5388496