PSI6206

SKU: orb1223825

Description

PSI-6206 (RO2433) is a selective HCV RNA polymerase inhibitor.

Key Properties

• CAS Number: 863329-66-2
• MW: 260.22
• Purity: >98% (HPLC)
• Formula: C₁₀H₁₃FN₂O₅
• SMILES: O=C1NC(C=CN1[C@@H]2O[C@H](CO)[C@@H](O)[C@]2(F)C)=O
• Target: HCV
• Solubility: DMSO: 10 mM

Bioactivity

• In Vitro:
  PSI-6206 (RO 2433) is tested for anti-HCV activity in both a cell-based quantitative real-time RT-PCR assay and surrogate bovine viral diarrhea virus (BVDV) assays. PSI-6206 demonstrates no activity or cytoxicity in any assay. The formation of the 5′-triphosphate (TP) of PSI-6130 (PSI-6130-TP) and RO2433 (RO2433-TP) increases with time and reached steady state levels at 48 h. RO2433-TP also inhibits RNA synthesis by the native HCV replicase isolated from HCV replicon cells and the recombinant HCV polymerase NS5B. PSI-6206 (RO2433) is the deaminated derivative of PSI-6130, which is a potent and selective inhibitor of HCV NS5B polymerase.

Storage & Handling

• Storage: Storage temperature: -20°C. Stability: ≥ 2 years
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

GS-331007 | RO 2433

Quick Database Links

Gene Symbol

HCV