PSI-6206

SKU: orb1306444

Description

PSI-6206 (RO 2433) is a potent and selective inhibitor of the hepatitis C virus (HCV) RNA-dependent RNA polymerase (NS5B). It is a research chemical used in vitro to study viral replication mechanisms and has been evaluated in preclinical models for its antiviral activity against HCV genotypes.

Research Area

Infectious Disease & Virology, Protein Biochemistry

Key Properties

• CAS Number: 863329-66-2
• MW: 260.22
• Purity: 99.79% (May vary between batches)
• Formula: C₁₀H₁₃FN₂O₅
• SMILES: C[C@]1(F)[C@@H](O[C@H](CO)[C@H]1O)N2C(=O)NC(=O)C=C2
• Target: HCV Protease
• Solubility: 10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (7.69 mM);DMSO:60 mg/mL (230.57 mM)

Bioactivity

• In Vitro:
  PSI-6206 (RO2433), a deaminated derivative of PSI-6130, a potent and selective inhibitor of HCV NS5B polymerase, has been evaluated for its anti-HCV efficacy employing both a cell-based quantitative real-time RT-PCR assay and surrogate bovine viral diarrhea virus (BVDV) assays. It showed no activity or cytotoxicity in these assays. The formation of 5′-triphosphate (TP) forms of PSI-6130 (PSI-6130-TP) and RO2433 (RO2433-TP) progressively increased, achieving steady state levels after 48 hours. Notably, RO2433-TP effectively inhibits RNA synthesis by both the native HCV replicase from HCV replicon cells and the recombinant HCV polymerase NS5B, highlighting its potential mechanism of action against HCV replication.

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

PSI 6206, PSI6206, PSI-6206, RO 2433, RO2433, RO-2433, 2'-deoxy-2'-fluoro-2'-C-methyluridine, inhibit, Inhibitor, Hepatitis C virus, HCV, HCV Protease, HCV replicon, HCVProtease, GS 331007, GS331007, GS-331007

Compound Identifiers

PubChem CID

11311503