Protopine

SKU: orb1223348

Description

Protopine is discontinued (controlled substance). Protopine is a benzylisoquinoline alkaloid occurring in opium poppy, Corydalis tubers and other plants of the family papaveraceae, like Fumaria officinalis. It has been found to inhibit histamine H1 receptors and platelet aggregation, and acts as an analgesic.

Key Properties

• CAS Number: 130-86-9
• MW: 353.37
• Purity: >98% (HPLC)
• Formula: C₂₀H₁₉NO₅
• SMILES: CN1CCc2cc3c(cc2C(=O)Cc2c(C1)c1c(cc2)OCO1)OCO3
• Target: mTOR
• Solubility: DMSO : 12.5 mg/mL. 35.37 mM

Bioactivity

• In Vivo:
  Animal model: 5-hydroxy-DL-tryptophan (5-HTP)-induced mice model. Dosage: 5, 10, 20 mg/kg. Administration: i.p. Result: Increased the number of 5-HTP-induced head twitch response (HTR). Decreased the immobility time tested in the Tail suspension test (TST).
• In Vitro:
  Western blot analysis WB Cell line: HepG2, Huh7. Concentration: 10, 20, 40 μM. Incubation time: 24 h. Result: Induced the cleavage of caspase-3 and caspase-9.Decreased Bcl-2 and Bcl-xl level. Induced the release of mitochondrial protein cytochrome c into the cytosol.

Storage & Handling

• Storage: Storage temperature: -20°C. Stability: ≥ 2 years
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Protopine | Biflorine | Fumarine | Corydinine

Quick Database Links

Gene Symbol

mTOR