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Protocadherin Gamma (pan) antibody

Protocadherin Gamma (pan) antibody

Catalog Number: orb150759

DispatchUsually dispatched within 2-3 weeks
$ 567.00
Catalog Numberorb150759
CategoryAntibodies
DescriptionMouse monoclonal to Protocadherin Gamma (Biotin). The protocadherin gamma gene cluster is one of three related clusters tandemly linked on chromosome five. These gene clusters have an immunoglobulin-like organization, suggesting that a novel mechanism may be involved in their regulation and expression. The gamma gene cluster includes 22 genes divided into 3 subfamilies. Subfamily A contains 12 genes, subfamily B contains 7 genes and 2 pseudogenes, and the more distantly related subfamily C contains 3 genes. The tandem array of 22 large, variable region exons are followed by a constant region, containing 3 exons shared by all genes in the cluster. Each variable region exon encodes the extracellular region, which includes 6 cadherin ectodomains and a transmembrane region. The constant region exons encode the common cytoplasmic region. These neural cadherin-like cell adhesion proteins most likely play a critical role in the establishment and function of specific cell-cell connections in the brain. Alternative splicing has been described for the gamma cluster genes..
Species/HostMouse
ClonalityMonoclonal
Clone NumberS159-5
Tested applicationsICC, IHC, WB
ReactivityHuman, Mouse, Rat
IsotypeIgG1
ImmunogenFusion protein corresponding to amino acids 808-931 (C-terminal cytoplasmic constant domain) of mouse Protocadherin-gamma-A1 that is shared by all 22 Gamma-protocadherins (A subfamily amino acids ~807-930, B subfamily amino acids ~789-912 and C subfamily amino acids ~818-941). 99% identity with human (123/124 amino acids).
Concentration1 mg/ml
Dilution rangeWB (1:1000), ICC/IF (1:100)
ConjugationBiotin
MW100kDa
TargetProtocadherin Gamma
Entrez93709
UniProt IDQ91XZ0
NCBINP_291062.1
StorageConjugated antibodies should be stored at 4°C
Buffer/PreservativesPBS pH 7.4, 50% glycerol, 0.1% sodium azide *Storage buffer may change when conjugated
Alternative namesPCDH gamma A antibody, PCDH-gamma-A antibody, PCDH
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NoteFor research use only
Application notes1 µg/ml of SMC-454 was sufficient for detection of Protocadherin gamma (pan) in 20 µg of rat brain lysate by colorimetric immunoblot analysis using Goat anti-mouse IgG:HRP as the secondary antibody.
Expiration Date12 months from date of receipt.
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