PROTAC YAP degrader-1

SKU: orb2665489

Description

PROTAC YAP degrader-1 is a bifunctional chimera that induces YAP degradation and blocks its nuclear translocation. It is composed of a Demethyl-NSC682769-based YAP ligand linked to an (R,S,R)-AHPC E3 ligase recruiter via an Acid-PEG2-C2-Boc spacer. This tool compound enables the study of Hippo pathway signaling in cancer research through targeted protein degradation in cellular models.

Research Area

Cancer Biology, Pharmacology & Drug Discovery, Stem Cell & Developmental Biology

Key Properties

• MW: 995.19
• Formula: C₅₆H₆₂N₆O₉S
• Target: PROTACs,YAP

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Quick Database Links

Gene Symbol

PROTACs,YAP