PROTAC TEAD degrader-1

SKU: orb3134295

Description

PROTACTEAD degrader-1 (Compound 27) is a PROTAC degrader of the transcriptional enhanced associate domain (TEAD). It selectively degrades Flag TEAD2 through a ubiquitin-protease-dependent mechanism, with a DC50 of 54.1 nM in 293T cells. This compound inhibits the proliferation of NF2-deficient NCI-H226 cells, showing an IC50 of 0.21 μM, and modulates the expression of yes-associated protein (YAP) target genes.

Research Area

Pharmacology & Drug Discovery, Stem Cell & Developmental Biology

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Key Properties

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Formula	C₄₄H₄₁F₃N₆O₇
Target	PROTACs,YAP

Storage & Handling

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Storage	-20°C
Expiration Date	12 months from date of receipt.
Disclaimer	For research use only

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Gene Symbol

PROTACs,YAP

Protocol Information

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CAS Number:	2971850-47-0
MW:	499.32
Formula:	C₂₅H₁₈BrF₃N₂O

CAS Number:	2417720-74-0
MW:	317.26
Formula:	C₁₇H₁₀F₃NO₂

PROTAC TEAD degrader-1

Description

Research Area

Images & Validation

Key Properties

Storage & Handling

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