PROTAC TEAD degrader-2

SKU: orb3177176

Description

PROTACTEAD degrader-2 (Compound 31) is a potent TEAD1 PROTAC degrader with a DC50 of 0.6 nM. It inhibits the YAP/TAZ-TEAD interaction with an IC50 of 1.8 nM and shows significant selective inhibitory activity against YAP-dependent cancer cells, effectively suppressing YAP-mediated transcriptional activity. This compound is applicable in mesothelioma and glioma research.

Research Area

Pharmacology & Drug Discovery, Stem Cell & Developmental Biology

Key Properties

• CAS Number: 2918762-17-9
• MW: 896.43
• Formula: C₄₉H₅₂ClF₂N₅O₇
• SMILES: O=C(N)C1=CC=C(OC)C(F)=C1C=2C(Cl)=C(F)C=C3OC(C=4C=CC=CC4)(CNC5CCC(C(=O)NCCCCCC=6C=CC=C7C(=O)N(CC76)C8C(=O)NC(=O)CC8)CC5)C(C32)C
• Target: PROTACs,YAP

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Quick Database Links

Gene Symbol

PROTACs,YAP