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PROTAC TEAD1/IAP degrader-2

SKU: orb3211527

Description

PROTAC TEAD1/IAP degrader-2 is an IAP-recruiting TEAD1 PROTAC degrader with a DC50 of 170 nM for TEAD1 in NCI-H2052 cells. It exhibits moderate antiproliferative activity in mesothelioma cells that depend on the Hippo pathway. PROTAC TEAD1/IAP degrader-2 also inhibits CTGF expression, though less effectively than the TEAD inhibitor VT-107, and is applicable for mesothelioma research.

Images & Validation

Key Properties

TargetIAP,YAP,PROTACs

Storage & Handling

Storage-20°C
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

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Protocol Information