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PROTAC SMARCA2 degrader-35

SKU: orb3175257

Description

Compound PROTACSMARCA2 degrader-35 (Compound 43) acts as a selective degrader of SMARCA2 with a DC50 of less than 0.1 μM. It demonstrates anticancer properties by halting the cell cycle and inhibiting DNA replication in cancer cells lacking SMARCA4, thereby controlling their proliferation and growth.

Research Area

Cell Biology, Molecular Biology, Pharmacology & Drug Discovery

Images & Validation

Key Properties

CAS Number3032998-97-0
MW769.79
FormulaC39H38F3N9O5
SMILESC(F)(F)[C@]12N(C=3C(NC1)=NN=C(C3)C4=C(O)C(F)=CC=C4)C[C@H](OC5=CC=C(CN6CCN(CC6)C=7C=C8C(=CC7)CN(C8=O)[C@@H]9C(=O)NC(=O)CC9)C=N5)C2
TargetPROTACs,DNA/RNA Synthesis

Storage & Handling

Storage-20°C
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

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Protocol Information