PROTAC SMARCA2/4-degrader-35

SKU: orb2695256

Description

PROTAC SMARCA2/4-degrader-35 (Example 43) potently degrades SMARCA2 and SMARCA4 proteins with a DC50 below 2.5 nM. This bifunctional molecule is a valuable chemical probe for investigating chromatin remodeling and oncogenic roles of these ATPases in cancer biology, applicable in both cellular and in vivo research models.

Research Area

Neuroscience, Pharmacology & Drug Discovery

Key Properties

• CAS Number: 2933253-85-9
• MW: 1020.23
• Formula: C₅₆H₆₉N₁₃O₆
• SMILES: NC1=NC=2N(C=C(N2)C3=C(O)C=CC=C3)C=C1C4=CN(C[C@@H]5C[C@@H](OC6CCN(CC7CCN(CC7)C=8C=C([C@H](C(=O)N9[C@H](C(N[C@@H](C)C%10=CC=C(C=C%10)C%11=CC=NN%11C)=O)C[C@@H](O)C9)C(C)C)ON8)CC6)C5)N=C4
• Target: PROTACs

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Compound Identifiers

PubChem CID

168901896