PROTAC SGK3 degrader-1

SKU: orb1707857

Description

SGK3-PROTAC1 is a heterobifunctional degrader that recruits the VHL E3 ligase to SGK3, leading to its proteasomal degradation. This compound, CAS 5017-88-83-4, has been shown to inhibit cancer cell proliferation in vitro, including countering GDC0941-induced proliferation, making it a valuable tool for studying SGK3 biology in oncology research.

Research Area

Metabolism Research, Pharmacology & Drug Discovery, Signal Transduction

Key Properties

• CAS Number: 2381320-35-8
• MW: 1157.38
• Formula: C₅₇H₇₃FN₁₀O₁₁S₂
• SMILES: Cc1ncsc1-c1ccc(CNC(=O)[C@@H]2C[C@@H](O)CN2C(=O)[C@@H](NC(=O)COCCOCCOCCCCCCN2CCO[C@@H](COc3nc(nc4[nH]ncc34)-c3ccc(NS(=O)(=O)c4cc(C)ccc4F)cc3)C2)C(C)(C)C)cc1
• Target: PROTACs,SGK

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Compound Identifiers

PubChem CID

139035049