PROTAC HER2 degrader-1

SKU: orb3135940

Description

PROTACHER2 degrader-1 is a highly selective HER2 PROTAC degrader with a DC50 of 69 nM and a Dmax of 96%. It effectively inhibits HER2-positive cell proliferation and tumor growth by inducing sustained HER2 degradation and strongly inhibiting downstream pathways (AKT and ERK). Additionally, PROTACHER2 degrader-1 can induce apoptosis in BT-474 cells and is useful for researching HER2-positive cancers.

Research Area

Cardiovascular Research, Cell Biology, Pharmacology & Drug Discovery, Signal Transduction

Key Properties

• CAS Number: 2897640-93-4
• MW: 910.03
• Formula: C₄₉H₅₅N₁₁O₇
• SMILES: O=C1C2=CC=C(C=C2C(=O)N1C3C(=O)NC(=O)CC3)NCCCCCCCN4CCN(CC4)CCCOC5=CC6=NC=NC(NC7=CC=C(OC=8C=CN9N=CN=C9C8)C(=C7)C)=C6C=C5OC
• Target: EGFR,Apoptosis,PROTACs,Akt,ERK

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Quick Database Links

Gene Symbol

EGFR,Apoptosis,PROTACs,Akt,ERK