PROTAC IDO1 Degrader-1

SKU: orb1692981

Description

PROTAC IDO1 Degrader-1 is a novel small molecule that induces the ubiquitin-proteasome degradation of IDO1 via CRBN E3 ligase recruitment (DC50 = 2.84 µM). This degradation mechanism can be applied in cancer immunotherapy research, as it has been shown to enhance the antitumor activity of HER2-targeted CAR-T cells in vitro.

Research Area

Metabolism Research, Pharmacology & Drug Discovery

Key Properties

• CAS Number: 2488851-89-2
• MW: 966.816
• Formula: C₄₀H₅₃BrFN₉O₁₃
• SMILES: O\N=C(/Nc1ccc(F)c(Br)c1)c1nonc1NCCNCCOCCOCCOCCOCCOCCOCCOCCNc1cccc2C(=O)N(C3CCC(=O)NC3=O)C(=O)c12
• Target: PROTACs

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Compound Identifiers

PubChem CID

162640820