PROTAC GSPT1 degrader-2

SKU: orb2664562

Description

PROTACGSPT1 degrader-2 (Compound A) is a potent molecular glue degrader of GSPT1, achieving >95% degradation. Its analog, GSPT1 degrader-8, demonstrates potent anti-proliferative activity in HL-60 cells (IC50 = 10 nM), supporting its use in cancer research and targeted protein degradation studies.

Key Properties

• CAS Number: 3024909-61-0
• MW: 708.21
• Formula: C₃₈H₃₈ClN₇O₅
• SMILES: O=C1NC(=O)C(N2C(=O)C3=CC=C(C=C3C2=O)N4CCC(CN5C(=O)N(C=6C=CC=C(C6)C=7C=NC=8NC=C(C8C7Cl)CC)CCC5)CC4)CC1

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Compound Identifiers

PubChem CID

172420089