PROTAC ERRα ligand 2

SKU: orb1301446

Description

This compound is a potent PROTAC-based inverse agonist of estrogen-related receptor α (ERRα), exhibiting an IC50 of 5.67 nM. It serves as a valuable chemical tool for studying ERRα function and degradation in cancer metabolism and energy homeostasis research, applicable in both cellular and biochemical assays.

Research Area

Metabolism Research

Key Properties

• CAS Number: 2306388-57-6
• MW: 445.31
• Purity: 98.00% (May vary between batches)
• Formula: C₂₀H₁₃F₆NO₄
• SMILES: COc1cc(\C=C(/C#N)C(O)=O)ccc1OCc1ccc(cc1C(F)(F)F)C(F)(F)F
• Target: Estrogen Receptor/ERR,Estrogen/progestogen Receptor
• Solubility: 10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (4.49 mM);DMSO:10 mM

Bioactivity

• Target IC50:
  ERRα:5.67 nM

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Estrogen Receptor, Estrogen Receptor/ERR, EstrogenReceptor, ERR, ERRα, inhibit, Inhibitor, PROTAC ERRa ligand 2, PROTAC ERRalpha ligand 2, PROTAC ERRα ligand 2, PROTAC ERRα ligand2, PROTAC ERRα ligand-2, progestogenReceptor, progestogen Receptor

Compound Identifiers

PubChem CID

139291005