His-TERRα

SKU: orb3177194

Description

His-TERRα is an ERRα PROTAC degrader. By using a single amino acid (His) as an E3 ligase ligand, His-TERRα leverages the N-end rule pathway to induce target protein degradation, markedly reducing molecular size and thus earning the designation mini-PROTAC. It significantly inhibits the proliferation and migration of MCF7 breast cancer cells and is useful for breast cancer research.

Key Properties

• CAS Number: 2408835-49-2
• MW: 695.68
• Formula: C₃₁H₂₈F₃N₉O₅S
• SMILES: O(C1=C(C(F)(F)F)C=C(C#N)C=C1)C2=C(OC)C=C(C=C3C(=O)N(CC4=CN(CCCNC([C@H](CC5=CN=CN5)N)=O)N=N4)C(=O)S3)C=C2
• Target: Estrogen Receptor/ERR,PROTACs

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Quick Database Links

Gene Symbol

Estrogen Receptor/ERR,PROTACs