PROTAC ERRα ligand 1

SKU: orb1308355

Description

This compound is a potent and selective ERRα antagonist, with IC50 values of 0.04 μM for ERRα and 2.8 μM for ERRγ. It serves as a key ligand for PROTAC development, enabling the targeted degradation of ERRα for research into its role in cancer, metabolism, and other cellular pathways in vitro.

Research Area

Metabolism Research

Key Properties

• CAS Number: 1264754-13-3
• MW: 420.36
• Purity: 99.45% (May vary between batches)
• Formula: C₁₉H₁₁F₃N₂O₄S
• SMILES: O(C1=C(C(F)(F)F)C=C(C#N)C=C1)C2=C(OC)C=C(/C=C\3/C(=O)NC(=O)S3)C=C2
• Target: Estrogen/progestogen Receptor,Estrogen Receptor/ERR
• Solubility: DMSO:120 mg/mL (285.47 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:4 mg/mL (9.52 mM)

Bioactivity

• Target IC50:
  ERRγ:2.8 μM|ERRα:0.04 μM

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Inhibitor, ERR, ERRα, ERRγ, Estrogen Receptor, EstrogenReceptor, Estrogen Receptor/ERR, inhibit, progestogen Receptor, progestogenReceptor, PROTAC ERRa ligand 1, PROTAC ERRalpha ligand 1, PROTAC ERRα ligand 1, PROTAC ERRα ligand1, PROTAC ERRα ligand-1

Compound Identifiers

PubChem CID

46916268