MS 154

SKU: orb1690091

Description

MS 154 is a cereblon-based PROTAC degrader that selectively targets mutant EGFR. It potently degrades mutant EGFR protein, inhibits downstream signaling, and suppresses proliferation in relevant lung cancer cell lines, while sparing wild-type EGFR cells. It has demonstrated bioavailability in mouse models following intraperitoneal administration.

Research Area

Cardiovascular Research, Pharmacology & Drug Discovery, Signal Transduction

Key Properties

• CAS Number: 2550393-21-8
• MW: 901.42
• Formula: C₄₆H₅₄ClFN₈O₈
• SMILES: O=C1C=2C(C(=O)N1C3C(=O)NC(=O)CC3)=CC=CC2OCCCCCCCCNC(CCN4CCN(CCCOC5=CC6=C(C=C5OC)N=CN=C6NC7=CC(Cl)=C(F)C=C7)CC4)=O
• Target: PROTACs,Others,EGFR

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Compound Identifiers

PubChem CID

145996534