Proguanil hydrochloride

SKU: orb1302902

Description

Research Area

Cell Biology, Infectious Disease & Virology, Metabolism Research, Molecular Biology

Images & Validation

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Key Properties

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CAS Number	637-32-1
MW	290.19
Purity	98.39%
Formula	C₁₁H₁₇Cl₂N₅
SMILES	Cl.Clc1ccc(NC(=N)NC(=N)NC(C)C)cc1
Target	Antifolate,DNA/RNA Synthesis,Parasite,Dehydrogenase
Solubility	DMSO:81.67 mg/mL (281.44 mM)

Bioactivity

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In Vitro	proguanil appeared to be a substrate of OCT1 and OCT2 with affinities of 8.1 and 9.0 μM, respectively
Cell Research	Sertoli cells obtained from sixteen to eighteen day-old-rats are cultured and treated with 0.3 μM to 10 μM of proguanil for 5 days after which Sertoli cell viability and nuclei integrity are determined. Also, the genetic expressions of transferrin and Glial cell line-derived neurotrophic factor are assessed. They are for reference only. Read more...
Animal Research	Proguanil is prepared in distilled water.Rats: Groups of ten to twelve-week-old rats are administered proguanil (2.9 mg/kg body weight) daily for 5 days and 6 weeks respectively. Thereafter, body and reproductive organ weights are taken, sperm parameters are analyzed, while the histology of the testis and epididymis are carried out. Also, serum levels of testosterone, luteinizing hormone and follicle stimulating hormone are determined. They are for reference only. Read more...

Storage & Handling

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Storage	Powder: -20°C for 3 years \| In solvent: -80°C for 1 year \| Shipping with blue ice/Shipping at ambient temperature.
Expiration Date	12 months from date of receipt.
Disclaimer	For research use only

Alternative Names

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DNA Synthesis, DNASynthesis, dihydrofolate reductase, Chlorguanide Hydrochloride, Chlorguanide hydrochloride, Chloroquanil, biguanide, Antifolate, antimalarial, embryotoxicity, Inhibitor, NADH dehydrogenase, Parasite, Paludrine hydrochloride, Paludrine Hydrochloride, inhibit, infection, Proguanil, Proguanil Hydrochloride, Proguanil hydrochloride, toxicity, RNASynthesis, RNA Synthesis, reproductive, thymidylate synthase

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Compound Identifiers

PubChem CID

12498 ↗

Key Properties

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No computed properties available.

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