Proguanil hydrochloride

• Catalog Number: orb1302902
• Category: Small Molecules
• Description: Proguanil hydrochloride
• CAS Number: 637-32-1
• Purity: 98.34%
• MW: 290.19
• SMILES: Cl.Clc1ccc(NC(=N)NC(=N)NC(C)C)cc1
• Formula: C₁₁H₁₇Cl₂N₅
• Biological Activity: Proguanil hydrochloride (Chloroquanil) is a biguanide compound which metabolizes in the body to form cycloguanil, an anti-malaria agent.Upon hydrolysis, Proguanil hydrochloride is converted to its active cyclic triazine metabolite, cycloguanil, by a cytochrome P450 dependent reaction. Cycloguanil selectively inhibits the bifunctional dihydrofolate reductase-thymidylate synthase of plasmodium parasite, thereby disrupting deoxythymidylate synthesis and ultimately blocking DNA and protein synthesis in the parasite.
• Note: For research use only
• Expiration Date: 12 months from date of receipt.