Cycloguanil hydrochloride

SKU: orb1301804

Description

Cycloguanil hydrochloride is the active metabolite of the antimalarial proguanil, functioning as a potent dihydrofolate reductase inhibitor with selectivity for the Plasmodium enzyme. It is widely used in antimalarial research for both in vitro enzymatic assays and in vivo efficacy studies in animal models of malaria.

Research Area

Infectious Disease & Virology, Metabolism Research

Key Properties

• CAS Number: 152-53-4
• MW: 288.18
• Purity: 99.46% (May vary between batches)
• Formula: C₁₁H₁₄ClN₅.ClH
• SMILES: Cl.CC1(C)N=C(N)N=C(N)N1c1ccc(Cl)cc1
• Target: Drug Metabolite,Parasite
• Solubility: 10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (6.94 mM);DMSO:20 mg/mL (69.4 mM);H2O:5 mg/mL (17.35 mM)

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Parasite, inhibit, Inhibitor, Chloroguanide Triazine, Cycloguanil, Cycloguanil Hydrochloride, Cycloguanil hydrochloride, DrugMetabolite, Drug Metabolite

Compound Identifiers

PubChem CID

9048