Progesterone

SKU: orb1310573

Description

Progesterone is a key steroid hormone involved in menstrual cycle regulation and pregnancy maintenance. It is widely utilized in biomedical research, including the establishment of in vivo melasma models and in vitro studies of hormonal signaling pathways.

Research Area

Metabolism Research, Neuroscience, Pharmacology & Drug Discovery

Key Properties

• CAS Number: 57-83-0
• MW: 314.46
• Purity: 99.89% (May vary between batches)
• Formula: C₂₁H₃₀O₂
• SMILES: C[C@@]12[C@@]3([C@]([C@]4([C@](C)(CC3)[C@@H](C(C)=O)CC4)[H])(CCC1=CC(=O)CC2)[H])[H]
• Target: Opioid Receptor,Progesterone Receptor,Endogenous Metabolite,Estrogen/progestogen Receptor
• Solubility: DMSO:47.48 mg/mL (150.99 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (6.36 mM);Ethanol:31.5 mg/mL (100.17 mM);Methanol:< 1 mg/mL (insoluble)

Bioactivity

• In Vivo:
  Twenty-one days after dorsal medial thalamic nuclei damage, rats treated with progesterone exhibited reduced neuronal degeneration. In female 3xTg-AD mice, progesterone negated the advantageous effects against Abeta accumulation, yet it did not affect behavioral performance. During the Morris water maze spatial navigation task, progesterone-treated rats demonstrated less impairment compared to control rats.
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• In Vitro:
  Progesterone drives a series of events in which luminal cells may furnish basal cells with Wnt4 and RANKL signals, which in turn respond by upregulating homologous receptors, transcriptional targets, and markers of the cell cycle. Progesterone exhibits a biphasic effect on the proliferation of breast cancer cells; it stimulates growth during the initial cell cycle and subsequently impedes cell progression at the G1/S phase.
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Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Inhibitor, ER, EndogenousMetabolite, Endogenous Metabolite, Estrogen Receptor, EstrogenReceptor, Opioid Receptor, OpioidReceptor, NR3C3, inhibit, Pregn-4-ene-3,20-dione, progestogenReceptor, ProgesteroneReceptor, Progesterone, Progesterone Receptor, progestogen Receptor, κ-opioid receptor

Compound Identifiers

PubChem CID

5994