Procyanidin B2

SKU: orb1300222

Description

Procyanidin B2

Research Area

Immunology & Inflammation, Metabolism Research, Signal Transduction

Key Properties

• CAS Number: 29106-49-8
• MW: 578.52
• Purity: 99.64% (May vary between batches)
• Formula: C₃₀H₂₆O₁₂
• SMILES: O[C@@H]1Cc2c(O)cc(O)c([C@@H]3[C@@H](O)[C@H](Oc4cc(O)cc(O)c34)c3ccc(O)c(O)c3)c2O[C@@H]1c1ccc(O)c(O)c1
• Target: Reactive Oxygen Species,NOD,ROS
• Solubility: DMSO:83.33 mg/mL (144.04 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (3.46 mM)

Bioactivity

• In Vivo:
  Procyanidin B2 from cinnamon inhibited AGE accumulation in diabetic rat kidney and ameliorated AGE mediated pathogenesis of DN.
• In Vitro:
  Procyanidin B2 exerts both antioxidant and pro-oxidant properties by interacting with H2O2 and metal ions.
• Animal Research:
  Streptozotocin-induced diabetic rats were fed with either 3% cinnamon or 0.002% Procyanidin B2(PCB2)-fraction in diet for 12weeks. Biochemical analysis of blood and urine was performed at the end of experiment. Evaluation of glomerular markers that serve as indicators of renal function was done by immunohistochemistry, immunoblotting and qRT-PCR. Supplementation of diabetic rats with cinnamon and PCB2-fraction prevented glycation mediated RBC-IgG cross-links and HbA1c accumulation in diabetes rats. Cinnamon and PCB2-fraction also inhibited the accumulation of N-carboxy methyl lysine (CML), a prominent AGE in diabetic kidney.

Storage & Handling

• Storage: keep away from direct sunlight,keep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Inhibitor, inhibit, NLRP3, Reactive Oxygen Species, ReactiveOxygenSpecies, Proanthocyanidin B 2, Proanthocyanidin B2, Proanthocyanidin B-2, Procyanidin B 2, Procyanidin B2, Procyanidin B-2

Compound Identifiers

PubChem CID

122738