Procaine hydrochloride

SKU: orb1310278

Description

Procaine hydrochloride

Research Area

Cell Biology, Epigenetics & Chromatin, Infectious Disease & Virology, Molecular Biology, Neuroscience, Pharmacology & Drug Discovery

Key Properties

• CAS Number: 51-05-8
• MW: 272.77
• Purity: 99.22%
• Formula: C₁₃H₂₀N₂O₂·HCl
• SMILES: Cl.CCN(CC)CCOC(=O)c1ccc(N)cc1
• Target: AChR,DNA/RNA Synthesis,Antibacterial,NMDAR,Sodium Channel,5-HT Receptor,Histone Demethylase
• Solubility: Ethanol:< 1 mg/mL (insoluble or slightly soluble);DMSO:55 mg/mL (201.64 mM);H2O:50 mg/mL (183.3 mM)

Bioactivity

• Target IC50:
  nAChR:45.5 μM|Na+ channel:60 μM|NMDAR:0.296 mM|5-HT3:1.7 μM(Kd)
• In Vivo:
  Procaine exhibits the ability to bind to or antagonize nicotinic acetylcholine receptors and the 5-HT(serotonin) receptor-ion channel complex, as well as N-methyl-D-aspartate (NMDA) receptors. Its primary mechanism of action involves the inhibition of sodium ion influx by affecting the voltage-gated sodium channels on the neuronal cell membranes of peripheral nerves. This disruption of sodium ion flow prevents the generation of action potentials, thereby inhibiting signal transduction. Studies suggest that the receptor sites targeted by procaine are located on the cytoplasmic (internal) portion of the sodium channels.
• In Vitro:
  In anesthetized cats, Procaine (15 mg/kg) enhanced the cellular activity in the ventral hippocampal formation of the amygdala, the ventromedial hypothalamus, the septal nucleus, and the neocortex of the temporal lobe. Procaine acts as a stimulant for marginal system cells. Furthermore, Procaine facilitates the conduction of evoked stimulatory activity from the amygdala to the ventromedial hypothalamus.

Storage & Handling

• Storage: Powder: -20°C for 3 years | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

5HTReceptor, 5HT Receptor, 5-HT3, DNA/RNA Synthesis, DNA Synthesis, DNASynthesis, duration, Inhibitor, Novocaine HCl, inhibit, multiple, nAChR, onset, NMDA receptor, HistoneDemethylase, Histone Demethylase, RNASynthesis, RNA Synthesis, SodiumChannel, Sodium Channel, Sodium channel, targets, Procaine HCl, Procaine Hydrochloride, Procaine hydrochloride, Procaine

Compound Identifiers

PubChem CID

5795