Mepivacaine hydrochloride

SKU: orb1225946

Description

Mepivacaine is a tertiary amine used as a local anesthetic.(In Vitro):Mepivacaine hydrochloride binds to specific voltage-gated sodium ion channels in neuronal cell membranes, which inhibits both sodium influx and membrane depolarization. This leads to a blockage of nerve impulse initiation and conduction and results in a reversible loss of sensation. Compared to other local anesthetics, this agent has a more rapid onset and moderate duration of action.Mepivacaine hydrochloride has a reasonably rapid onset (more rapid than that of procaine) and medium duration of action (shorter than that of procaine).Mepivacaine hydrochloride displays a preferential use-dependent block of Na(v)1.8, S(-)-bupivacaine displays a preference for TTXs Na(+) channels.

Key Properties

• CAS Number: 1722-62-9
• MW: 282.81
• Purity: >98% (HPLC)
• Formula: C₁₅H₂₂N₂O·HCl
• SMILES: Cl.CN1CCCCC1C(=O)NC1=C(C)C=CC=C1C
• Target: Sodium Channel
• Solubility: Ethanol: 8 mg/mL (28.28 mM); Water: 57 mg/mL (201.54 mM); DMSO: 3 mg/mL (10.6 mM)

Bioactivity

• In Vitro:
  Mepivacaine hydrochloride binds to specific voltage-gated sodium ion channels in neuronal cell membranes, which inhibits both sodium influx and membrane depolarization. This leads to a blockage of nerve impulse initiation and conduction and results in a reversible loss of sensation. Compared to other local anesthetics, this agent has a more rapid onset and moderate duration of action. Mepivacaine hydrochloride has a reasonably rapid onset (more rapid than that of procaine) and medium duration of action (shorter than that of procaine). Mepivacaine hydrochloride displays a preferential use-dependent block of Na(v)1.8, S(-)-bupivacaine displays a preference for TTXs Na(+) channels.

Storage & Handling

• Storage: Storage temperature: -20°C. Stability: ≥ 2 years
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Quick Database Links

Gene Symbol

Sodium Channel