Prednisolone

SKU: orb1308182

Description

Prednisolone is a synthetic glucocorticoid used extensively in research for its potent anti-inflammatory and immunosuppressive effects. It is a key tool for modeling inflammation and immune responses in both in vitro cellular assays and in vivo animal studies.

Research Area

Metabolism Research, Pharmacology & Drug Discovery

Key Properties

• CAS Number: 50-24-8
• MW: 360.44
• Purity: 99.59% (May vary between batches)
• Formula: C₂₁H₂₈O₅
• SMILES: CC12CC(O)C3C(CCC4=CC(=O)C=CC34C)C1CCC2(O)C(=O)CO
• Target: Glucocorticoid Receptor,Endogenous Metabolite
• Solubility: 10% DMSO+40% PEG300+5% Tween 80+45% Saline:4 mg/mL (11.1 mM);Ethanol:10 mg/mL (27.74 mM);DMSO:131 mg/mL (363.44 mM)

Bioactivity

• In Vivo:
  In quadriceps and soleus muscles, Prednisolone (0.75 mg/kg) is effective in reducing the populations of macrophages, CD4(+) T cells, CD8+ T cells, and eosinophils. At a dosage of 50 mg/kg, Prednisolone suppresses the levels of mRNA for NOS stimulated by lipopolysaccharides in neutrophils of mice. Furthermore, Prednisolone mediates its anti-inflammatory effects by decreasing the expression of cell adhesion molecules.
• In Vitro:
  In guinea pigs, Prednisolone significantly reduces the partial pressure of oxygen in the pleural lining (PL-oxygen tension). In rats, Prednisolone (5 mg/kg) induces diaphragm contraction and histological alterations, resulting in an increased number of diaphragm bundles.

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Predonine, Prednisolone, corticosteroid, anti-inflammatory, inhibit, orally active, Metacortandralone, Hydroretrocortine, GlucocorticoidReceptor, Glucocorticoid Receptor, glucocorticoid, EndogenousMetabolite, Endogenous Metabolite, Inhibitor

Compound Identifiers

PubChem CID

4894