Pratensein

SKU: orb1297233

Description

Pratensein is a small molecule that transcriptionally upregulates scavenger receptor class B type I (SR-BI) in HepG2 cells. This compound is a valuable research tool for investigating SR-BI's role in hepatic cholesterol metabolism and HDL function in both in vitro and in vivo models of cardiovascular and metabolic disease.

Research Area

Signal Transduction

Key Properties

• CAS Number: 2284-31-3
• MW: 300.26
• Purity: 99.90%
• Formula: C₁₆H₁₂O₆
• SMILES: COc1ccc(cc1O)-c1coc2cc(O)cc(O)c2c1=O
• Target: NF-κB
• Solubility: DMSO:50 mg/mL (166.52 mM)

Bioactivity

• In Vitro:
  Protective effect of five isoflavones (formononetin, daidzein, Pratensein, calycosin and irilone) from Trifolium pratense on lipopolysaccharide-induced dopaminergic neurodegeneration was studied for the first time. The results showed that all five isoflavones attenuated LPS-induced decrease in dopamine uptake and the number of dopaminergic neurons in a dose-dependent manner in rat mesencephalic neuron-glia cultures. Moreover, they also significantly inhibited LPS-induced activation of microglia and production of tumor necrosis factor-alpha, nitric oxide and superoxide in mesencephalic neuron-glia cultures and microglia-enriched cultures. In addition, the rank order of protective potency of five isoflavones was: Pratensein>daidzein>calycosin>formononetin>irilone.

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

NF-κB, Nuclear factor-kappaB, Nuclear factor-κB, NFκB, NFkB, NF-kB, inhibit, impairment, Inhibitor, cognitive, Beta Amyloid, damage, AChR, BDNF, synapse, oxidative, Pratensein

Compound Identifiers

PubChem CID

5281803