Pratensein

SKU: orb1218380

Description

Pratensein as a novel transcriptional up-regulator of scavenger receptor class B type I in HepG2 cells.

Key Properties

• CAS Number: 2284-31-3
• MW: 300.3
• Purity: >98% (HPLC)
• Formula: C₁₆H₁₂O₆
• SMILES: COC1=C(C=C(C=C1)C2=COC3=CC(=CC(=C3C2=O)O)O)O
• Target: Others
• Solubility: In Vitro: DMSO : 50 mg/mL (166.52 mM)

Bioactivity

• In Vivo:
  Pratensein significantly attenuates neuronal degeneration and apoptosis in hippocampus. The over-expression in IL-1β and TNF-α as well as the extensive astrogliosis and microgliosis in hippocampus induced by Aβ1-42 are significantly reduced following administration of Pratensein. Pratensein treatment significantly suppresses the activation of NF-κB in hippocampus. Pratensein is able to increase the levels of synaptophysin and brain-derived neurotrophic factor (BDNF). Pratensein (20 mg/kg; p.o. ; once daily for 3 weeks) ameliorates learning and memory deficits in Aβ1-42 rat model of Alzheimer’s disease. Animal model: Male 10-week old Wistar rats. Dosage: 20 mg/kg. Administration: p.o. ; once daily for 3 weeks. Result: The spatial learning and memory ability of rats was improved.
  Read more...

Storage & Handling

• Storage: Storage temperature: -20°C. Stability: ≥ 2 years
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Quick Database Links

Gene Symbol

Others