PPY A

SKU: orb1704209

Description

PPY A is a potent small molecule inhibitor effective against both wild-type and T315I mutant forms of Abl kinase, with IC50 values of 20 nM and 9 nM, respectively. It suppresses the proliferation of cells transformed by Bcr-Abl, making it a valuable tool for in vitro studies of drug-resistant chronic myeloid leukemia.

Research Area

Cardiovascular Research, Signal Transduction

Key Properties

• CAS Number: 875634-01-8
• MW: 372.42
• Purity: 98.77% (May vary between batches)
• Formula: C₂₂H₂₀N₄O₂
• SMILES: O=C(C1=CN=CC(=C1)C2=CN=C3NC=C(C=4C=CC=CC4OC)C3=C2)N(C)C
• Target: Bcr-Abl
• Solubility: DMSO:10 mg/mL (26.85 mM)

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

PPY A, BcrAbl, Bcr-Abl1

Compound Identifiers

PubChem CID

16750094