PPQ-102

SKU: orb1223614

Description

PPQ-102 is a potent CFTR inhibitor which can completely inhibited CFTR chloride current with IC 50approximately 90 nM.

Key Properties

• CAS Number: 931706-15-9
• MW: 438.48
• Purity: >98% (HPLC)
• Formula: C₂₆H₂₂N₄O₃
• SMILES: O=C1N(C)C(C(C(N1C)=O)=C2C3=CC=CC=C3)=C4N2C5=C(C=CC=C5)NC4C6=CC=C(C)O6
• Target: CFTR
• Solubility: DMSO: 5 mg/mL

Bioactivity

• In Vitro:
  Cell Viability Assay Cell line: E13.5 embryonic kidneys (embryonic kidney organ culture model of PKD) Concentration: 0, 0.5, 5 μM Incubation time: 3 or 4 days. Result: Remarkablyreduced the number and size of renal cysts formed in the 8-Br-cAMP-containing medium (showed ~60% inhibition of cyst formation at 0.5 μM, near complete absence of cysts at 2.5 and 5 μM). Remarkable reduced cyst size over 1 and 2 days in the 8-Br-cAMP-containing medium.

Storage & Handling

• Storage: Storage temperature: -20°C. Stability: ≥ 2 years
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

CFTR Inhibitor IV | Cystic Fibrosis Transmembrane Conductance Regulator Inhibitor IV

Quick Database Links

Gene Symbol

CFTR