PP7

SKU: orb1309221

Description

PP7 is a small molecule inhibitor that potently disrupts the PB1-PB2 protein-protein interaction with an IC50 of 8.6 µM. This compound is a valuable research tool for studying influenza A virus replication mechanisms in both cellular and biochemical assays.

Research Area

Infectious Disease & Virology, Signal Transduction

Key Properties

• CAS Number: 433238-84-7
• MW: 377.22
• Purity: 99.67% (May vary between batches)
• Formula: C₁₈H₁₄Cl₂N₂O₃
• SMILES: CCOC1=CC=C(\C=C2/C(=O)NN(C2=O)C2=CC=C(Cl)C(Cl)=C2)C=C1
• Target: Influenza Virus
• Solubility: DMSO:1 mg/mL (2.65 mM)

Bioactivity

• Target IC50:
  PB1-PB2:8.6 μM |Viral polymerase activity:9.5 μM|Influenza virus subtypes A (H1N1) pdm09:1.4 μM(EC50)
• In Vitro:
  PP7 showed inhibition against viral polymerase activity (IC50=9.5 μM). PP7 exhibited antiviral activities against influenza virus subtypes A (H1N1)pdm09(EC50=1.4 μM), A(H7N9) and A(H9N2) in cell cultures.
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Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

InfluenzaVirus, Influenza A, Influenza Virus, inhibit, Inhibitor, PP7, PP-7, PP 7

Compound Identifiers

PubChem CID

2290641