Poziotinib hydrochloride

SKU: orb1219474

Description

Poziotinib hydrochloride irreversibly inhibits EGFR (HER1 or ErbB1), including EGFR mutants, HER2, and HER4, thereby inhibiting the proliferation of tumor cells that overexpress these receptors. It is an orally bioavailable, quinazoline-based pan epidermal growth factor receptor (EGFR or HER) inhibitor with potential antineoplastic activity.

Images & Validation

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Key Properties

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CAS Number	1429757-68-5
MW	527.8
Purity	>98% (HPLC)
Formula	C₂₃H₂₂Cl₃FN₄O₃
SMILES	Cl.COc1cc2ncnc(Nc3ccc(Cl)c(Cl)c3F)c2cc1OC1CCN(CC1)C(=O)C=C
Target	EGFR

Storage & Handling

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Storage	Storage temperature: -20°C. Stability: ≥ 2 years
Expiration Date	12 months from date of receipt.
Disclaimer	For research use only

Alternative Names

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NOV120101 hydrochloride,HM 781-36B hydrochloride

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Gene Symbol

EGFR

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