Pomolic acid

SKU: orb1297234

Description

Pomolic acid is a bioactive triterpenoid with demonstrated anti-cancer and anti-inflammatory properties. It induces apoptosis in SK-OV-3 ovarian cancer cells via both intrinsic mitochondrial and extrinsic death receptor pathways, supporting its use in oncology research for in vitro mechanistic studies.

Research Area

Cell Biology, Epigenetics & Chromatin, Infectious Disease & Virology, Protein Biochemistry, Signal Transduction

Key Properties

• CAS Number: 13849-91-7
• MW: 472.7
• Purity: 99.79%
• Formula: C₃₀H₄₈O₄
• SMILES: [H][C@@]12CC[C@]3(C)[C@]([H])(CC=C4[C@]5([H])[C@](C)(O)[C@H](C)CC[C@@]5(CC[C@@]34C)C(O)=O)[C@@]1(C)CC[C@H](O)C2(C)C
• Target: Apoptosis,Caspase,HIV Protease,AMPK
• Solubility: DMSO:60 mg/mL (126.93 mM);10% DMSO+90% Corn Oil:2.5 mg/mL (5.29 mM)

Bioactivity

• In Vitro:
  Oleanolic acid (1) was identified as an anti-HIV principle from several plants, including Rosa woodsii (leaves), Prosopis glandulosa (leaves and twigs), Phoradendron juniperinum (whole plant), Syzygium claviflorum (leaves), Hyptis capitata (whole plant), and Ternstromia gymnanthera (aerial part). It inhibited HIV-1 replication in acutely infected H9 cells with an EC50 value of 1.7 microg/mL, and inhibited H9 cell growth with an IC50 value of 21.8 microg/mL [therapeutic index (T. I.) 12.8]. Pomolic acid, isolated from R. woodsii and H. capitata, was also identified as an anti-HIV agent (EC50 1.4 microg/mL, T. I. 16.6). Although ursolic acid did show anti-HIV activity (EC50 2.0 microg/mL), it was slightly toxic (IC50 6.5 microg/mL, T. I. 3.3). A new triterpene (11) was also isolated from the CHCl3-soluble fraction of R. woodsii, though it showed no anti-HIV activity. The structure of 11 was determined to be 1beta-hydroxy-2-oxoPomolic acid by spectral examination. Based on these results, we examined the anti-HIV activity of oleanolic acid- or Pomolic acid-related triterpenes isolated from several plants. In addition, we previously demonstrated that derivatives of betulinic acid, isolated from the leaves of S. claviflorum as an anti-HIV principle, exhibited extremely potent anti-HIV activity

Storage & Handling

• Storage: keep away from direct sunlight | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

ROS, Prostate, Randialic acid A, Pomolic acid, pentacyclic triterpene, Caspase, cancer, Apoptosis, AMPK, HIV Protease, HIVProtease, HIV, Inhibitor, inhibit

Compound Identifiers

PubChem CID

382831