Pomolic acid

SKU: orb1218873

Description

Pomolic acid has anti-cancer, anti-inflammatory and apoptotic activities, it can induce apoptosis in SK-OV-3 cells, which is mediated by the mitochondrial-mediated intrinsic and death receptor-induced extrinsic pathways.

Key Properties

• CAS Number: 13849-91-7
• MW: 472.7
• Purity: >98% (HPLC)
• Formula: C₃₀H₄₈O₄
• SMILES: C[C@H](CC[C@]1([C@@H]2C3=CC[C@H]([C@@](C)(CC4)[C@@H](CC5)C(C)(C)[C@H]4O)[C@]5(C)[C@]3(C)CC1)C(O)=O)[C@@]2(C)O
• Target: PKA
• Solubility: In Vitro: DMSO : 100 mg/mL (211.55 mM)

Bioactivity

• In Vitro:
  Randialic acid A (Pomolic acid) induces apoptosis ofGBM cells as demonstrated by DNA fragmentation. Pomolic acid-induced apoptosis is dependent on reactive oxygen species (ROS) production. It also induces uncoupling of mitochondria membrane potential and activation of caspase-3 and -9.

Storage & Handling

• Storage: Storage temperature: -20°C. Stability: ≥ 2 years
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Quick Database Links

Gene Symbol

PKA