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Pomolic acid

SKU: orb1218873

Description

Pomolic acid has anti-cancer, anti-inflammatory and apoptotic activities, it can induce apoptosis in SK-OV-3 cells, which is mediated by the mitochondrial-mediated intrinsic and death receptor-induced extrinsic pathways.

Images & Validation

Key Properties

CAS Number13849-91-7
MW472.7
Purity>98% (HPLC)
FormulaC30H48O4
SMILESC[C@H](CC[C@]1([C@@H]2C3=CC[C@H]([C@@](C)(CC4)[C@@H](CC5)C(C)(C)[C@H]4O)[C@]5(C)[C@]3(C)CC1)C(O)=O)[C@@]2(C)O
TargetPKA
SolubilityIn Vitro: DMSO : 100 mg/mL (211.55 mM)

Bioactivity

In Vitro
Randialic acid A (Pomolic acid) induces apoptosis ofGBM cells as demonstrated by DNA fragmentation. Pomolic acid-induced apoptosis is dependent on reactive oxygen species (ROS) production. It also induces uncoupling of mitochondria membrane potential and activation of caspase-3 and -9.

Storage & Handling

StorageStorage temperature: -20°C. Stability: ≥ 2 years
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

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Protocol Information

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500 mg
200 mg
100 mg
5 mg
$ 590.00
10 mg
$ 870.00
25 mg
$ 1,390.00
50 mg
$ 1,880.00