Polymyxin B

SKU: orb1944475

Description

Polymyxin B is a polymyxin-class antibiotic that disrupts Gram-negative bacterial membranes by binding to lipopolysaccharide (LPS). It is a critical research tool for studying extensively drug-resistant (XDR) Gram-negative infections and endotoxemia in both in vitro and in vivo experimental models.

Research Area

Infectious Disease & Virology

Key Properties

• CAS Number: 1404-26-8
• Purity: 91.00% (May vary between batches)
• Target: Antibiotic,Antibacterial
• Solubility: H2O:16.67 mg/mL

Bioactivity

• In Vivo:
  Polymyxin B was administered intravenously once daily for seven consecutive days at a dose range of 5-20 mg/kg Polymyxin B. The treatment of PBMCs with Polymyxin B for six hours reduced TNF-α and IL-10 production. A nephrotoxicity endpoint was observed in the Sprague-Dawley rat model at the 20 mg/kg dose, whereas no such endpoint was observed at the 5 mg/kg dose.
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• In Vitro:
  10 μg/mL Polymyxin B, treated for 6 hours, reduced TNF-α and IL-10 production in human peripheral blood mononuclear cells (PBMCs).

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Antibiotic, Bacterial

Quick Database Links

Gene Symbol

Antibiotic,Antibacterial