(E)-2,6-Di-tertbutyl-4(4-(diethylamino)styryl)pyrylium TFA

• Catalog Number: orb2945017
• Category: Small Molecules
• Description: (E)-2,6-Di-tert-butyl-4-(4-(diethylamino)styryl)pyrylium TFA (Compound 4a) functions as a Gram-negative outer membrane permeabilizer by targeting Met47 in LptA to disrupt LptA/LptC interactions, exhibiting synergistic antibacterial activity. This compound, when in the form of (trifluoromethanesulfonate), enhances the efficacy of pol B against both wild-type and multi-drug resistant A. baumannii and E. coli strains. Additionally, (E)-2,6-Di-tert-butyl-4-(4-(diethylamino)styryl)pyrylium (trifluoromethanesulfonate) serves as an adjuvant for antibiotics combating multi-drug resistant Gram-negative bacteria.
• Target: Antibacterial
• MW: 515.629
• CAS Number: 2811663-45-1
• Formula: C₂₆H₃₆F₃NO₄S
• SMILES: C(S(=O)(=O)[O-])(F)(F)F.C(=C/C1=CC=C(N(CC)CC)C=C1)\C=2C=C(C(C)(C)C)[O+]=C(C(C)(C)C)C2
• Storage: -20°C
• Research Area: Infectious Disease & Virology
• Note: For research use only
• Expiration Date: 12 months from date of receipt.