Polygalacin D

SKU: orb1684305

Description

Polygalacin D

Research Area

Cell Biology

Key Properties

• CAS Number: 66663-91-0
• MW: 1209.4
• Purity: 98.95%
• Formula: C₅₇H₉₂O₂₇
• SMILES: [H][C@@]1(O[C@H]2[C@H](O)CO[C@@]([H])(O[C@H]3[C@H](C)O[C@@]([H])(O[C@@H]4[C@@H](O)[C@@H](O)CO[C@H]4OC(=O)[C@]45CCC(C)(C)C[C@@]4([H])C4=CC[C@]6([H])[C@@]7(C)C[C@H](O)[C@H](O[C@]8([H])O[C@H](CO)[C@@H](O)[C@H](O)[C@H]8O)[C@](C)(CO)[C@]7([H])CC[C@@]6(C)[C@]4(C)C[C@H]5O)[C@H](O)[C@@H]3O)[C@@H]2O)OC[C@](O)(CO)[C@H]1O
• Target: IAP,Apoptosis
• Solubility: 10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (1.65 mM);DMSO:55 mg/mL (45.48 mM)

Bioactivity

• In Vitro:
  In this study, we investigate the effects of seven platycodin saponins o the activities of inducible nitric oxide synthase (iNOS) and cyclooxygenase II (COX-2) in lipopolysaccharide (LPS)-induced RAW 264.7 macrophages. We found that 2'-O-acetyl Polygalacin D (S1), platycodin A (S2), platycodin D (S3), and Polygalacin D (S6) inhibited LPS-induced NO production in a concentration dependent manner. furthermore , these compounds inhibite the expression of LPS-induced iNOS and COX-2 protein and mRNA without an appreciable cytotoxic effect on RAW 264.7 macrophages, and could suppress induction by LPS of pro-inflammatory cytokines such as prostag andin E2 (PGE2). Treatment with these compounds of RAW 264. Cells transfected with a Reporter construct indicated a reduced level of LPS-induced nuclear factor-kappaB (NF-kappaB) activity and effectively lowered NF-kappaB binding as measured by electrophoretic mobility shift assay (EMSA) the suppression of NF-kappaB activation appears to occur throug the prevention of inhibitor kappaB (IkappaB) degradation. In vivo platycodin saponin mixture (PS) and S3 protected mice fro the lethal effects of LPS the 89% lethality induced by LPS/galactosamine was reduced to 60% and 50% when PS and S3, respectively were administered simultaneously with LP

Storage & Handling

• Storage: keep away from direct sunlight,keep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Disclaimer: For research use only

Alternative Names

Apoptosis, COX, Inhibitor, NOS, inhibit, IAP, Polygalacin D, PGE

Compound Identifiers

PubChem CID

46173909