Polygalacic acid

SKU: orb1692689

Description

Polygalacic acid (Virgaureagenin G), a triterpenoid from Polygala tenuifolia, modulates cholinergic activity by reducing AChE and elevating ChAT and ACh levels in brain regions. It also inhibits IL-1β-induced Wnt/β-catenin and MAPK pathways in chondrocytes, supporting its research application in neurodegenerative and osteoarthritis studies.

Research Area

Neuroscience, Protein Biochemistry

Key Properties

• CAS Number: 22338-71-2
• MW: 504.70
• Purity: 99.82%
• Formula: C₃₀H₄₈O₆
• SMILES: CC1(C)CC[C@@]2([C@H](O)C[C@]3(C)C(=CC[C@@H]4[C@@]5(C)C[C@H](O)[C@H](O)[C@@](C)(CO)[C@@H]5CC[C@@]34C)[C@H]2C1)C(O)=O
• Target: AChR,MMP,Cholinesterase (ChE)
• Solubility: DMSO:91.00 mg/mL (180.31 mM)

Bioactivity

• In Vivo:
  METHODS: Polygalacic acid (Virgaureagenin G) (3, 6 and 12 mg/kg, oral, 14 days), and intraperitoneal injection of scopolamine (1 mg/kg, 14 days) were used to induce memory impairment. Memory-related behaviors were assessed using the Morris water maze; cholinergic and neuroinflammatory activities were measured in brain tissue; superoxide dismutase activity malondialdehyde and reduced glutathione content in the brain were measured. RESULTS Scopolamine treatment significantly increased escape latency, reduced the number of crossovers, and shortened the time spent in the target quadrant, and Polygalacic acid (Virgaureagenin G) reversed these scopolamine-induced effects; Polygalacic acid (Virgaureagenin G) significantly Improved cholinergic system reactivity, such as reduced acetylcholinesterase (AChE) activity, increased choline acetyltransferase (ChAT) activity, and increased acetylcholine (ACh) levels in the hippocampus and frontal cortex; Polygalacic acid (Virgaureagenin G) also showed Significantly improved neuroinflammation and oxidative stress in mice.
• In Vitro:
  Method: Polygalacic acid (Virgaureagenin G) (1,5,10,20,30,40,50μM) was used to treat BV2 and N2a cells, and Polygalacic acid (Virgaureagenin G) (50μM) was selected to treat Aβ42 (10,30,40μM). Treated BV2 cells and observed cell viability. RESULTS Polygalacic acid (Virgaureagenin G) has no toxicity to BV2 and N2a cells; the conditioned medium pretreated with 50 μM Polygalacic acid (Virgaureagenin G) can significantly increase the viability of N2a cells and significantly reduce the apoptosis of N2a neurons induced by Aβ42. Mortality rate.

Storage & Handling

• Storage: store at low temperature,keep away from direct sunlight | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Cholinesterase (ChE), AChR, AChE, MMP, inhibit, Matrix metalloproteinases, Inhibitor, Polygalacic acid, Virgaureagenin G

Compound Identifiers

PubChem CID

71463855