Polygalacic acid

SKU: orb1222501

Description

Polygalacic acid(PA) significantly improves cholinergic system reactivity, as indicated by decreased acetylcholinesterase (AChE) activity, increases choline acetyltransferase (ChAT) activity, and elevates levels of acetylcholine (ACh) in the hippocampus and frontal cortex, PA also significantly ameliorates neuroinflammation and oxidative stress in mice; suggest that PA might exert a significant neuroprotective effect on cognitive impairment, driven in part by the modulation of cholinergic activity and neuroinflammation. Polygalacic acid shows significant postingestive effects on Spodoptera littoralis larvae.

Key Properties

• CAS Number: 22338-71-2
• MW: 504.7
• Purity: >98% (HPLC)
• Formula: C₃₀H₄₈O₆
• SMILES: O=C(O)[C@]53CCC(C)(C)C[C@H]5C4=CC[C@H]2[C@@](C)(CC[C@@H]1[C@]2(C)C[C@H](O)[C@H](O)[C@@]1(C)CO)[C@]4(C)C[C@H]3O
• Target: Lipoxygenase
• Solubility: In Vitro: DMSO : 50 mg/mL (99.07 mM)

Bioactivity

• In Vitro:
  Polygalacic acid (0-100 μM; 24 hours) significantly decreases the mRNA expressions of MMP-3, MMP-9, MMP-13, and COX-2, which are significantly increased by IL-1β, in a dose-dependent manner. Polygalacic acid (0-100 μM; 6 hours) decreases the expression of phosphor-p38, phosphor-Erk, and phosphor-Jnk induced by IL-1β, phosphor-p65 is not reduced by polygalacic acid. RT-PCR Cell line: Chondrocyte cells. Concentration: 50 μM; 100 μM. Incubation time: 24 hours. Result: Suppressed IL-1β-induced COX-2, MMP3, MMP9, and MMP13 mRNA expression. Western blot analysis. Cell line: Chondrocyte cells. Concentration: 50 μM; 100 μM. Incubation time: 6 hours. Result: Inhibited the IL-1β-induced activation of the MAPK pathway in chondrocytes.

Storage & Handling

• Storage: Storage temperature: -20°C. Stability: ≥ 2 years
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Quick Database Links

Gene Symbol

Lipoxygenase