Polydatin

SKU: orb1304212

Description

Polydatin (Piceid), a resveratrol glycoside from Polygonum cuspidatum, inhibits platelet aggregation and modulates lipid ratios. Research in vitro and in vivo shows it reduces ICAM-1 expression, alters calcium flux, and activates KATP channels in cardiovascular and inflammatory cell models.

Research Area

Cell Biology, Signal Transduction

Key Properties

• CAS Number: 27208-80-6
• MW: 390.38
• Purity: 98.94% (May vary between batches)
• Formula: C₂₀H₂₂O₈
• SMILES: OC[C@H]1O[C@@H](Cc2cc(O)cc(\C=C\c3ccc(O)cc3)c2)[C@H](O)[C@@H](O)[C@@H]1O
• Target: Apoptosis,Autophagy,Mitophagy,NF-κB
• Solubility: 10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (5.12 mM);DMSO:60 mg/mL (153.7 mM)

Bioactivity

• In Vivo:
  Polydatin could significantly increase the activity of SOD and the heart rate, attenuate myocardial pathological damage, decrease MDA content, slightly increase arterial pressure and GSH-Px activity, reduce intervals of QRS, QT and ST, and lower FFA content. The combination of polydatin and vitamin C could significantly increase arterial pressure and heart rate, decrease QRS interval and slightly reduce ST and QT intervals, significantly attenuate myocardial pathological damage, increase the activities of GSH-Px,T-SOD, Na+ K+ -ATPase, and Ca2+ Mg2+ -ATPase, elevate phosphocreatine (PCr) and adenosine triphosphate (ATP) contents, slightly increase adenosine diphosphate (ADP) and total adenine nucleotide (TAN) contents and PCr/ATP, and significantly decrease the contents of MDA and FFA, when compared with those in the DOX group.
• In Vitro:
  Polydatin protects cerebral cells from ischemic damages via improvement of microcirculation and inhibition of platelet aggregation. In addition, polydatin inhibits ICAM-1 expression in endothelial cells stimulated by lipopolysaccharide; it also attenuates adhesion between white blood cells and endothelial cells.
• Cell Research:
  The effect of polydatin on mMEC viability is evaluated with an MTT assay. mMECs are incubated in the presence or absence of various concentrations of polydatin (25, 50 and 100 μg/mL) and DEX (100 μg/mL) for 24 h. Next, 20 μL of MTT (5 mg/mL) is added to each well and incubated for 4 h. After the supernatants are removed and the formazan is dis solved with 150 μL of DMSO in each well, the optical density (OD) value is measured at 570 nm on a microplate reader.

Storage & Handling

• Storage: keep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Autophagy, Apoptosis, Inhibitor, inhibit, Mitophagy, Mitochondrial Autophagy, NFκB, NF-kB, NFkB, NF-κB, Piceid, Polydotin Peceid, Polydatin

Compound Identifiers

PubChem CID

134692030