(E/Z)-Polydatin

SKU: orb1304822

Description

(E/Z)-Polydatin

Research Area

Metabolism Research

Key Properties

• CAS Number: 65914-17-2
• MW: 390.38
• Purity: 100.00%
• Formula: C₂₀H₂₂O₈
• SMILES: OC[C@H]1O[C@@H](Oc2cc(O)cc(\C=C\c3ccc(O)cc3)c2)[C@H](O)[C@@H](O)[C@@H]1O
• Target: Phospholipase
• Solubility: DMSO:45 mg/mL (115.27 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (5.12 mM);Ethanol:< 1 mg/mL (insoluble or slightly soluble);H2O:< 1 mg/mL (insoluble or slightly soluble)

Bioactivity

• In Vivo:
  Polydatin is a PLA2 inhibitor that reduces the expression of sPLA2-IIA mRNA and the activity of phospholipase A2. It also increases the expression of Clara cell secretory proteins, thereby mitigating lipopolysaccharide-induced lung injury.
• In Vitro:
  In a study involving mice with sepsis induced by cecal ligation and puncture, polydatin (15/45/100 mg/kg) was found to inhibit the production of serum TNF-α and IL-6, the protein expression of lung cyclooxygenase-2 and inducible NO synthase isoforms, and the activation of NF-κB, thereby reducing mortality and lung injury in a dose-dependent manner. The LD50 of polydatin in mice was determined to be 1 g/kg (i.p.).

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

cuspidatum, (E/Z) Polydatin, (E/Z)-Piceid, (E/Z)Polydatin, (E/Z)-Polydatin, Polygonum, Polydatin, PLA2

Compound Identifiers

PubChem CID

5281718