PluriSIn #2

SKU: orb1693860

Description

PluriSIn #2 is a selective inhibitor of topoisomerase II alpha (topo2α) transcription. It demonstrates cytotoxic activity specifically against undifferentiated, leukemogenic human pluripotent stem cells (hPSCs). This small molecule is a valuable research tool for studying cancer stem cell biology and potential anti-leukemia strategies in vitro.

Research Area

Molecular Biology

Key Properties

• CAS Number: 56563-17-8
• MW: 249.2
• Purity: 98.00% (May vary between batches)
• Formula: C₁₁H₈FN₃O₃
• SMILES: Fc1cn(C(=O)Nc2ccccc2)c(=O)[nH]c1=O
• Target: Topoisomerase
• Solubility: DMSO:4 mg/mL (16.05 mM)

Bioactivity

• In Vitro:
  PluriSIn #2 (20 μM; 12 hours) treatment reduces TOP2A expression at the protein level.A 24h exposure of PluriSIn #2 (20 μM) is sufficient to induce massive cell death in hPSCs, but doesn't affect the viability of various other cell types derived from them. Western Blot AnalysisCell Line: B153 and HUES9 human pluripotent stem cells (hPSCs)
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Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

PluriSIn #2

Compound Identifiers

PubChem CID

92451