PluriSln 1

SKU: orb1307292

Description

PluriSIn 1 (NSC 14613) is a potent and selective small molecule inhibitor of stearoyl-CoA desaturase 1 (SCD1). It is widely used in research to investigate the role of lipid metabolism, particularly oleic acid synthesis, in the regulation of human pluripotent stem cell (hPSC) self-renewal and differentiation in both in vitro and in vivo models.

Research Area

Cell Biology, Stem Cell & Developmental Biology

Key Properties

• CAS Number: 91396-88-2
• MW: 213.24
• Purity: >98%
• Formula: C₁₂H₁₁N₃O
• SMILES: O=C(NNC1=CC=CC=C1)C1=CC=NC=C1
• Target: ER/Golgi
• Solubility: Soluble in DMSO (up to 25 mg/ml).

Bioactivity

• In Vivo:
  PluriSIn 1 causes central cell death by activating apoptosis.PluriSIn 1 produces ER stress by interacting with hPSCs.PluriSIns 1 (20 μM) has an inhibitory effect on teratoma formation by undifferentiated hPSCs, and it also inhibits the development of mPSCs and mouse embryos.PluriSIns 1 (20 μM) induces a protein-like response to hPSCs by interacting with hPSCs. PluriSIns 1 (20 μM) induced an approximately 30% reduction in protein synthesis by interacting with hPSCs. In hPSCs, PluriSIns 1 produced potent, rapid and selective cytotoxicity and induced a ~65% reduction in stearoyl coenzyme A dehydrogenase activity.
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• Cell Research:
  Relative cell numbers are determined by fixating the cells with 0.5% glutardialdehyde and staining with methylene blue dissolved in 0.1 M boric acid (pH 8.5). Color extraction is performed using 0.1 M hydrochloric acid, and the staining (which is proportional to cell number) is quantitated by measuring absorbance at 650 nM.(Only for Reference)
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Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

4-Pyridinecarboxylic acid 2-phenylhydrazide

Compound Identifiers

PubChem CID

225362