Pladienolide B

SKU: orb1741531

Description

Pladienolide B is a macrolide SF3B1 inhibitor isolated from Streptomyces species that disrupts pre-mRNA splicing. Its antitumor activity, demonstrated in vitro and in vivo, makes it a valuable tool for researching hematological malignancies such as leukemia and lymphoma.

Research Area

Cell Biology

Key Properties

• CAS Number: 445493-23-2
• MW: 536.7
• Purity: 98.27% (May vary between batches)
• Formula: C₃₀H₄₈O₈
• SMILES: C([C@@H](/C=C/C=C(\C)/[C@@H]1[C@@H](C)/C=C/[C@H](OC(C)=O)[C@](C)(O)CC[C@@H](O)CC(=O)O1)C)[C@@H]2[C@@]([C@@H]([C@H](CC)O)C)(O2)[H]
• Target: Apoptosis

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Compound Identifiers

PubChem CID

16202130