PKM2 inhibitor

SKU: orb1221645

Description

MDK4882, also known as PKM2 inhibitor or compound 3k, is a PKM2 inhibitor. MDK4882 was first described in Eur J Med Chem. 2017;138:343-352. Currently there is no formal name. We temporarily name it MDK4882 for the convenience of communication, in which the last 4 digit of CAS# is used. MDK4882 displayed more potent PKM2 inhibitory activity than the reported optimal PKM2 inhibitor shikonin. MDK4882 also showed nanomolar antiproliferative activity toward a series of cancer cell lines with high expression of PKM2 including HCT116, Hela and H1299 with IC50 values ranging from 0.18 to 1.56 μM. MDK4882 exhibited more cytotoxicity on cancer cells than normal cells.

Research Area

Metabolism Research; Pharmacology & Drug Discovery

Key Properties

• CAS Number: 94164-88-2
• MW: 345.48
• Purity: >98% (HPLC)
• Formula: C₁₈H₁₉NO₂S₂
• SMILES: CC1=C(C(=O)c2ccccc2C1=O)CSC(=S)N1CCCCC1
• Target: PKM1| PKM2
• Solubility: DMSO : 5.56 mg/mL 16.09 mM; H2O : < 0.1 mg/mL

Bioactivity

• In Vitro:
  PKM2-IN-1 (compound 3k) is a pyruvate kinase M2 (PKM2) inhibitor with an IC50 of 2.95±0.53 μM. Results show that most of the tested compounds exhibit some degree of PKM2 inhibition and some compounds, such as PKM2-IN-1 (compound 3k) and 6d, display more potent activity than the positive control shikonin. The representative compounds PKM2-IN-1, 6d display dose-dependent inhibition of PKM2 with less inhibition of PKM1 and PKL like shikonin. Among all tested compounds, the most potent compounds are 3a, PKM2-IN-1 and 3r, which exhibit IC50 values against HCT116 and Hela cells ranging from 0.39 to 0.41 μM, 0.18 to 0.29 μM and 0.18 to 0.38 μM, respectively.
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Storage & Handling

• Storage: Storage temperature: -20°C. Stability: ≥ 2 years
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

PKM2 inhibitor | MDK4882

Quick Database Links

Gene Symbol

PKM1| PKM2